Toward rigorous assessment of statistical significance in functional genomics
نویسندگان
چکیده
منابع مشابه
Statistical Challenges in Functional Genomics
On February 12, 2001 the Human Genome Project announced that it had assembled a draft physical map of the human genome the genetic blueprint for a human being. Now the challenge is to annotate this map, by understanding the functions of genes and their interplay with proteins and the environment to create complex, dynamic living systems. This is the goal of functional genomics. Recent technolog...
متن کاملAnoEST: toward A. gambiae functional genomics.
Here, we present an analysis of 215,634 EST and cDNA sequences of a major vector of human malaria Anopheles gambiae structured into the AnoEST database. The expressed sequences are grouped into clusters using genomic sequence as template and associated with inferred functional annotation, including the following: corresponding Ensembl gene prediction, putative orthologous genes in other species...
متن کاملFunctional Genomics of the Grape - Xylella Interaction : toward the Identification
Susceptible Vitis vinifera responds to Xylella infection with a massive re-direction of gene transcription involving >800 genes with strong statistical support. This number is increased from previous estimates based on use of a more sensitive and robust statistical method known as linear models for microarray data (LIMMA). The transcriptional response to Xylella infection is characterized by in...
متن کاملStatistical and Practical Significance of Articles at Sports Biomechanics Conferences
Background. The importance of using statistical approaches has increased and became necessary for researchers and specialists in sports biomechanics because they need more objective and accurate methods to increase knowledge. Objectives. Evaluate the reality of using practical significance in the articles published in scientific conferences in the biomechanical sport. Methods. One hundred twe...
متن کاملIntestinal permeability: functional assessment and significance.
The intestinal epithelium demonstrates differential properties, providing both barrier and transport functions with respect to luminal molecules. Intestinal permeability relates to barrier function and, although it is the ‘permeation’ of molecular markers that is used to measure ‘permeability’, the terms are often confused. Permeability is that property of the intestinal epithelium or of a memb...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Genetics
سال: 2001
ISSN: 1061-4036,1546-1718
DOI: 10.1038/87382